Tuesday 

 

09:00-10:15

Registration w/coffee

10:15-10:25

Opening v. Claus Loland

10:25-12:30

 

 

Session 1. New kids on the monoamine transporter block - Implications for treatment of psychiatric and substance use disorders

Chair: Lynette Daws, Univ. of Texas (US), co-chair: Sonia Susic, Medical Univ. of Vienna (AT)

 

Prof. Lynette Daws, Univ. of Texas (US)

Title: Unfaithful transporters: Insights into mechanisms of action of therapeutic and

abused drugs

 

Prof. Harald H. Sitte, Medical Univ. of Vienna (AT)

Title: Impact of plasma membrane constituents on transporters responsible for

monoamine clearance

 

Ass. Prof. T. Lee Gilman, Kent State Univ (US)

Title: Unmasking the functional contribution of PMAT to monoamine clearance

 

Post doc. Felix P. Mayer, Florida Atlantic Univ. (US)

Title: Dopamine transporters out of control: Disrupted regulation of dopamine clearance and a potential remedy via manipulation of opioid signaling

 

Ass. Prof. Ali Salahpour, Univ. of Toronto (CA)

Title: Structure activity relationship of DAT pharmacological chaperones

12:30-13:30

Lunch

13:30-14:15

 

Keynote Speaker: Nieng Yan, Princeton Univ. “Structural and mechanistic investigation of the human glucose transporters

14:15-14:35

Coffee break

14:35-16:15

Session 2. Structural and functional dynamics of transporters

Chairs: Ute Hellmich, Johs. Gutenberg University Mainz (DE); Torben Cordes, LMU Munich (DE)

 

Assoc. Prof. Oded Lewinson, Technion (IL)

Title: Conformational dynamics of the vitamin B12 ABC transporter BtuCD seen by smFRET

 

Prof. Enrica Bordignon, Ruhr Universität Bochum (DE)

Title: Dynamics of ABC transporters in cellular membranes: a milestone achievable with EPR

 

Prof. Dimitrios Stamou, Univ. of Copenhagen (DK)

Title: Off-cycle states and their role in function and regulation of transport

 

Ass. Prof. Thomas Stockner, Medical Univ. of Vienna (AT)

Title: Using MD simulations as magnification lens to investigate transporter function at all atom resolution

16:15-16:35

Break

 

 

16:35-18:15

Session 3. Heteromeric amino acid transporters

Chair: Manuel Palacín, Univ. de Barcelona (ES)  

 

Prof. Simon Newstead, Univ. of Oxford (UK)

Title: Structural basis of amino acid and peptide transport in eukaryotic cells

Prof. Manuel Palacín, Univ. de Barcelona (ES)

Title: Transport mechanisms of LAT transporters

 

Prof. Yoshikatsu Kanai, Osaka Univ. (JP)

Title: Structural and cellular signaling bases of anti-cancer therapeutics targeting amino acid transporter LAT1/CD98hc

 

Prof. Gaia Novarino, Inst. of Science and Technology (AT)

Title: Role of LAT1/CD98hc in autism and microcephaly

18:15-?

Welcome Reception

 

 

Wednesday

 

08:45-08:50

Welcome

08:50-10:30

 

Session 4. The neglected SLC6 transporters: Structure and function of GABA and glycine transporters

Chair: Petrine Wellendorph, Univ. of Copenhagen, co-chair: Stefanie Kickinger, Univ. Vienna

 

Prof. Azadeh Shahsavar, Aarhus Univ. (DK)

Title: Structural insights into the molecular mechanism underlying glycine reuptake inhibition

 

Prof. Klaus T. Wanner, LMU Munich (DE)

Title: Identification of new GAT Inhibitors by means of MS Binding Assays in Combination with Affinity Selection Mass Spectrometry

 

Prof. Baruch I. Kanner, Hebrew Univ. Medical School (IL)

Title: New Insights in the Gating Mechanism of the GABA transporter GAT-1

 

Post doc. Maria E. K. Lie, Univ. of Copenhagen (DK)

Title: Molecular Characterization of the Extrasynaptic GABA Transporters and their Pharmacological Potential in Ischemic Stroke

10:30-10:50

Coffee break

10:50-12:30

Session 5. Cancer metabolism – shaping metabolic flux through membrane transport

Chair: Louise Fets, MRC London Inst. of Medical Sciences (UK)

 

Professor Jared Rutter, University of Utah (US)

Title: Metabolite transport and cellular decisions

 

Assist. Prof. Costas Lyssiotis, University of Michigan Medical School (US)

Title: Metabolic networks in the tumour microenvironment

 

Group leader Susumu Hirabayashi, MRC London Inst. of Medical Sciences (UK)

Title: Elevated amino acid transporter expression drives tumourigenesis in response to diet-induced obesity

 

Post doc Emily Barnes, MRC London Inst. of Medical Sciences (UK)

Title: The role of lactate transport and metabolism in cancer and its therapeutic implications

12:30-14:15

Lunch & Poster Session 1

14:15-15:00

 

Keynote Speaker: Rob Edwards, UC San Francisco “Endocytic recycling mechanism dictates the mode of neurotransmitter release

15:00-15:20

Coffee break

 

 

15:20-17:00

Session 6. New developments in CLC structure, mechanisms and disease

Chair: Joseph Mindell, Natl. Inst. on Neurological Disorders and Stroke - NIH (US)

 

Principal Investigator Alessio Accardi, Weill Cornell Medical College (US)

Title: Role of an unexpected amino acid in the antiport mechanism of a CLC transporter

 

Prof. Merritt Maduke, Stanford Univ. (US)

Title: Development of a potent and specific inhibitor of the CLC-2 chloride channel enables investigation of CLC-2 as an epilepsy target in the CNS

 

Principal Investigator Michael Pusch, Instituto di Biofisica (IT)

Title: Mechanisms underlying intellectual disability caused by mutations in neuronal CLC chloride proton antiporters

 

Senior Investigator Joe Mindell, NINDS-NIH (US)

Title: What we learn about CLC mechanism from a novel, disease-causing mutation in a lysosomal ClC

19:00-?

Jazz Event

   

Thursday

 

08:45-08:50

Welcome

08:50-10:30

Session 7. Lipid gymnastics - Highlights on lipids translocation mechanisms

Chair: Chrisitine Ziegler, Univ. of Regensburg (DE)

 

Dr. Ahmad Reza Mehdipour, Max Planck Institute of Biophysics (DE)

Title: Molecular dynamics of substrate recognition and transport in lipid transporters

 

Prof. Camilo Perez, Univ. of Basel (CH)

Title: Defend the wall: Structure and mechanism of a pH sensing flippase

 

Prof. Cristina Paulino, Univ. of Groningen (NL)

Title:  The flips and flops of a scramblase story: conformational plasticity of TMEM16 scramblases under activating conditions

 

Dr. Chloé Martens, Univ. Libre de Bruxelles (BE)

Title: Structure of a multidrug transporter reveals molecular basis of polyspecific recognition

10:30-10:50

Coffee break

10:50-12:00

Young Scientists Session

12:00-13:45

Lunch & Poster Session 2

13:45-14:30

Keynote Speaker: Raimund Dutzler, Univ. of Zurich “The TMEM16 family of calcium activated lipid scramblases and ion channels

14:30-14:50

Coffee break

14:50-16:30

 

Session 8. Human ASCT2 - from structure to anticancer therapy

Chair: Dirk Slotboom, Univ. of Groningen (NL)

 

Post doc. Alisa Garaeva, Univ. of Groningen (NL)

Title: Interaction of substrates, lipids and inhibitors with ASCT2

 

Prof. Renae Ryan, Univ. of Sidney (AU)

Title: The split personality of SLC1A transporters: a chloride channel and a transporter

 

Prof. Christof Grewer, Univ. of Binghamton (US)

Title: Exploring glutamine transporter ASCT2 function:  From molecular mechanism to inhibitor development  

 

Senior Researcher Seungil Han, Pfizer Inc (US)

Title: Structural basis for the transport mechanism of the human glutamine transporter SLC1A5 (ASCT2)

 

Free evening

 

 

 

 

Friday

 

09:00-10:40

Session 9. SLC4- and SLC9 family acid-base transport proteins - from structure to human disease

Chair: Stine F. Pedersen, Univ. of Copenhagen (DK)

 

Adj. Prof. Joe R. Casey, University of Alberta (US)

Title: SLC4A11 mutations in human disease

 

Prof. David Drew, Stockholm Univ. (SE)

Title: Dissecting the proton transport pathway in electrogenic Na+/H+ antiporters

 

Prof. Ebbe Bødtkjer, Aarhus Univ. (DK)

Title: Bicarbonate transporters and sensors in breast carcinogenesis – insights from mouse models

 

Prof. Stine F. Pedersen, Univ. of Copenhagen (DK)

Title: Structural and functional insights into NHE1 regulation by kinases and phosphatases

10:40-11:00

Coffee break

11:00-12:40

 

Session 10. Molecular mechanisms of Na+-coupled neurotransmitter transport

Chair: Baruch Kanner, Hebrew Univ. Medical School (IL)

 

Prof. Gary Rudnick, Yale University (US) 

Title: New developments in Neurotransmitter Transport Mechanisms

 

Senior Investigator Lucy R. Forrest, Natl. Inst. on Neurological Disorders and Stroke - NIH (US)

Title: Insights into neurotransmitter transport from modeling and simulation

 

Assoc. Prof. Nicolas Reyes, Institut Pasteur (FR)

Title: Cation binding to human excitatory amino acid transporters

 

Prof. Christoph Fahlke, Forschungszentrum Jülich (DE) 

Title: Mechanisms of K+-coupled glutamate transport

12:40-13:45

Lunch

13:45-14:30

 

Keynote Speaker: Randy Blakely, Florida Atlantic Univ. “Fundamental and pathophysiological regulation of serotonin transporters

14:30-14:50

Coffee break

14:50-16:55

 

Session 11. Emerging roles for transporters in dopamine dysfunction in CNS disorders

Chair: Nikhil Urs, Univ. of Florida (US), co-chair: Ulrik Gether, Univ. of Copenhagen (DK)

 

Ass. Prof. Freja Herborg, Univ. of Copenhagen (DK)

Title: Disease-associated mutations in the dopamine transporter – modelling neuropsychiatric comorbidity in parkinsonism

 

Prof. Habibeh Khoshbouei, Univ. of Florida (US)

Title: iPSc-derived human-like dopamine neurons reveal a potential therapeutic target for Parkinson's disease

 

Post doc. Thomas Steinkellner, UC San Diego (US)

Title: Role for VGLUT2 in dopamine neuron vulnerability and Parkinson's disease

 

Ass. Prof. Nikhil Urs, Univ. of Florida (US)

Title: Role of PFC catecholamine transporters in regulating striatal dopamine neurotransmission in health and disease

 

Prof. Aurelio Galli, Univ. of Alabama at Birmingham (US)

Title: The dopamine transporter-syntaxin interactions regulates courting behaviors and dopamine homeostasis

18:00-?

Farewell Dinner

 

 

Cecevent Aps - Gadevangsvej 102, Gadevang - DK3400 - Hillerød - Phone +4525901212 - Bo@cecevent.dk